Progressive outer retinal necrosis syndrome: successful treatment with a new combination of antiviral drugs.

PURPOSE To describe a case of progressive outer retinal necrosis syndrome, successfully treated with a new combination of antiviral drugs. METHODS The patient was treated with a combined therapy of antiviral drugs that includes: intravenous acyclovir 10 mg/kg, three intravitreal injections of foscarnet (1200 microg) and a ganciclovir implant in the right eye. RESULTS The progressive outer retinal necrosis appeared to response dramatically with the combination of antiviral agents used over a period of 2 weeks with a final visual acuity of 20/80 at 3 months of follow up. CONCLUSIONS Intravitreal foscarnet combined with i.v. acyclovir and ganciclovir implant may represent an effective alternative treatment for PORN.